After step three, you have successfully deactivated Skype for Business from your computer, and you will not see it even if it is still on your computer. This step will clear all your profile cache for Business Skype and disable automatic sign-in when the app opens. Step 3: Click the Settings button again in the Skype for Business interface and select File and Exit in order.The app will automatically launch when I log in to Windows 10, launch the app in the foreground, and then right-click to confirm the changes. Step 2: Select the Personal option on the left.Step 1: Open Skype Settings for Business, go to Tools tab and select Options.In this method, to disable this feature to prevent it from starting, please follow the instructions below. Image by Alexandra_Koch from Pixabay Disable Skype For Business Via Skype Settings